Synthesis of axially chiral gold complexes and their applications in asymmetric catalyses

• Yin-wei Sun,
• Qin Xu and
• Min Shi

Beilstein J. Org. Chem. 2013, 9, 2224–2232, doi:10.3762/bjoc.9.261

• product in moderate yields and up to 29% ee. Keywords: asymmetric gold catalysis; chiral Au catalysts; gold-π interaction; NHC gold complex; Introduction After the long-held assumption of the non-reactivity of gold complexes, numerous reactions catalyzed by gold complexes have emerged in the last 2

• far, several axially chiral NHC–gold catalysts based on binaphthyl skeleton such as 1 and 2 [46][49] have been reported with good to excellent chiral inductions in asymmetric gold catalysis (Figure 1). Encouraged by these results, we attempted to develop novel types of axially chiral NHC–gold

Asymmetric Au-catalyzed cycloisomerization of 1,6-enynes: An entry to bicyclo[4.1.0]heptene

• Alexandre Pradal,
• Chung-Meng Chao,
• Patrick Y. Toullec and
• Véronique Michelet

Beilstein J. Org. Chem. 2011, 7, 1021–1029, doi:10.3762/bjoc.7.116

• comprehensive study on gold-catalyzed enantioselective synthesis of bicyclo[4.1.0]heptenes, focusing on the scope and limitations of such systems. Results and Discussion Optimization of the catalytic system Based on our ongoing program on asymmetric gold catalysis [46][49][50][51][52], and on literature reports